Abstract
Three novel three-membered ring sesquiterpenoids, named kissoone A (1), kissoone B (2), and its acetylated product, kissoone C (3), were isolated from the roots of Valeriana fauriei. Their structures were elucidated on the basis of spectroscopic analysis. Compounds
2 and 3 showed enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth
in PC 12D cells.
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Prof. Dr. Yasushi Ohizumi
Department of Pharmaceutical Molecular Biology
Graduate School of Pharmaceutical Sciences
Tohoku University
Sendai 980-8578
Japan
Phone: +81-22-795-6851
Fax: +81-22-795-6850
Email: ohizumi@mail.pharm.tohoku.ac.jp